What are Biomarkers?

Biomarkers are critical tools in drug discovery, development, and diagnostic phases. Biomarkers are made up of many different types of indicators that help you make quick and  informed decisions. They serve as surrogates for assessing the activity of candidate therapeutics and can be indispensable tools for validating targets, proving the mechanism of action, and predicting therapeutic efficacy, as well as alerting for potential toxicity.

However, the process of identifying and validating new disease-related and pharmacodynamic biomarkers is difficult. Biomarker identification is a multi-step and iterative process beginning early in the drug discovery stage, which helps build a strong biomarker testing strategy across all phases of development.

The biomarker services in Texas offered by plexision.com can help you translate them to the clinic and beyond while greatly accelerating candidate development and decreasing timelines.

Biomarker assays are becoming increasingly important in clinical development. The assays are also useful for identifying intermediate endpoints of success to decrease follow-up time.  The use of a specific biomarker assay can provide an early indication of drug efficacy.

Optimal biomarker assays create a knowledge framework for confident decision making to help minimize risk. With techniques like genomics, transcriptomics, proteomics, cytometry, and metabolomics, companies may use many different approaches to discover and develop biomarkers.

Biomarkers play a critical role in drug development methods as well as in the larger biomedical research enterprise. Understanding the relationship between measurable biological processes and clinical outcomes is vital to expanding the arsenal of medications for all conditions, and for increasing our understanding of normal and healthy physiology.

A robust analysis of study samples is important to optimize therapeutic benefit and discover biomarkers. Advance your therapeutic candidates through genomic and proteomic analysis.

 

● Effectively predict response and toxicity through potential candidate biomarker identification.

● Enhance your pharmacology data by determining qualitative and quantitative agent effects at the genomic and proteomic level.

● Maximize drug effects by comprehensively evaluating the mechanism of action and PD.

● Reduce potential toxicities by understanding the immune and morphological composition of relevant organs.

● Extend therapeutic benefit by improving the monitoring of disease progression and treatment persistence.

According to plexision.com, once biomarker validation is achieved, the biomarker is utilized in drug development for disease identification and/or treatment options. Biomarker discovery is critical in concept and safety studies for drug development. During the initial phase of drug discovery and development, biomarker research helps in identifying a suitable dose range. This is achieved by evaluating the effect of a specific dose of a drug on the biomarker.

Safety biomarkers, on the other hand, are essential to ensure the safe functioning of organs, such as the liver and kidneys, during drug treatment. Throughout drug development and the preclinical/clinical trials, biomarker analysis helps in maintaining the safety profile and measuring the efficacy of a drug compound.

  

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